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Berberine regulates gut microbiota, increases beneficial bacteria, decreases harmful bacteria, and enhances the gut barrier, thereby reducing LPS translocation and its mediated TLR4/NF-B pathway activation to inhibit liver inflammation

However, 1,2-dibromoethane was not included as a controlled substance in the "Montreal Protocol on Substances that Deplete the Ozone Layer"

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Vachiry et al., 2019)