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Emerging evidence indicates that chronic exposure to addictive substances can induce or exacerbate depressive symptoms through reward circuitry alterations, neuroinflammation, altered hypothalamic pituitary adrenal axis function, and mitochondrial dysfunction, thereby establishing a neurobiological milieu that favors drug induced depressive states

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EFSA J 15(8):04919 El-Dessouki AM, Galal MA, Awad AS, Zaki HF (2017) Neuroprotective effects of simvastatin and cilostazol in L-methionine-induced vascular dementia in rats

10.1007/BF00315104

Most modern cruise ships include mini-refrigerators in staterooms, but cruise line policies explicitly state these beverage mini-bars are not to be used to store medications that have specific temperature requirements since they dont maintain precise pharmaceutical refrigeration ranges

Morphologically, it is mainly manifested as ultrastructural changes of mitochondria, such as shrinkage of mitochondria, increased density of mitochondrial membrane, and rupture of mitochondrial cristae and outer membrane