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Su principal desventaja frente a otros antioxidantes orales es la baja biodisponibilidad del GSH nativo , lo que ha motivado el desarrollo de formulaciones liposomales y micelares, as como el uso de precursores como la N-acetilcistena (NAC) , que aportan cistena para la sntesis endgena de glutatin

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However, traditional forms of glutathione can be difficult for the body to absorb effectively