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At research doses of 0.252mg daily, AHK-Cu delivers approximately 0.050.4mg elemental copper per day well below the tolerable upper intake level of 10mg daily established by the NIH

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*Correspondence: Bai-Rong Xia, [email protected] These authors have contributed equally to this work This article was submitted to Cancer Metabolism, a section of the journal Frontiers in Oncology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The three phases are activation in weeks 14, remodeling in weeks 58, and maintenance in weeks 912