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Discovered in 1973 by Loren Pickart and shown in Nature to prolong liver cell survival 17 , it has since accumulated more than 50 years of peer-reviewed research on collagen and elastin synthesis, fibroblast activation, gene-expression modulation, and wound healing

Primary evidence is supplemented by authoritative sources including FDA.gov, NIH.gov, MayoClinic.org, and ClevelandClinic.org due to limited recent peer-reviewed publications on FDA status and long-term safety for this specific query

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The mechanistic story is plausible and, in places, elegant