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The following represents a theoretical ultra-conservative approach based on monotherapy principles: Hypothetical Ultra-Conservative Schedule: This extended 24-week titration period doubles the typical monotherapy escalation timeline , reflecting the complete absence of interaction data and the overlapping side effect profiles

PRP remains the standard treatment for PDR, but it may lead to permanent peripheral visual field loss, reduced night vision, or worsen existing DME, increasing its occurrence [37]

P., Koroleva, A., Lingvay, I., ONeil, P

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