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Therefore, some scholars have proposed the concept of "glutamine hijacking," which suggests that targeted inhibition of glutamine metabolism in tumor cells can alleviate glutamine competition in the tumor microenvironment, release glutamine for immune cell utilization, and promote anti-tumor immune response [134]

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It also decreased the expression of the PI3K/AKT/mTOR pathway and the NF-/TGF- pathway, inhibited CK18 and COX2 activity, increased the concentration of BAX and P53 proteins, and decreased Bcl-2, IL-6, IL-1, MMP2, and MMP9