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One small randomized controlled trial in 450 pregnant women in West Africa, without specified MTHFR genotype but at high risk for preeclampsia, found that supplementation with 15 mg of riboflavin daily was not effective in preventing the condition (29), but the study was likely underpowered to detect a significant effect

Conflict of interest The authors declare that they have known competing financial interests or personal relationships that could have appeared to influence the work reported in this manuscript

There is a significant risk of redness, burning, dryness, and sensitivity after treatment if you combine them