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Of note, the arousal stimulator noradrenalin, whose concentration in brain peaks during daytime, has been shown to induce oxidative stress and apoptosis in cultured oligodendrocyte progenitors (Khorchid et al., 2002), whereas acetylcholine that is elevated during the wake state and REM sleep, has been shown to promote mitotic expansion of oligodendrocyte progenitors (Paez-Gonzalez et al., 2014

While effective, their safety in high or prolonged exposure is a topic of ongoing scientific debate [22, 24]

& Young, J

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Whether that theoretical advantage translates to clinical benefit remains unproven

2.4 Experimental studies elucidate the pathogenic role of ferroptosis in Alzheimers disease A growing body of experimental evidence from animal and cellular models has clarified the mechanistic links between iron dysregulation and ferroptosis in Alzheimers disease (AD)