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Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes

Lancet 366 (9498), 17361743

Most drug targets identified using our drug deletion pipeline overlap with the predicted essential genes like SQLE, FASN and HMGCR or are members of the same pathways

Drug Metab Dispos 23(3):406414 Shear NH, Spielberg SP, Grant DM, Tang BK, Kalow W (1986) Differences in metabolism of sulfonamides predisposing to idiosyncratic toxicity

Astrocytes exacerbate neurodegeneration after they are activated and impair vascular repair and vasculature formation

Carpenter, A