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GLP-1 receptor agonists such as semaglutide reshaped obesity pharmacology by curbing appetite and improving glycemic control, but researchers hypothesized that recruiting the glucagon receptor could add a complementary axis increased energy expenditure and enhanced hepatic fat handling that a pure GLP-1 agonist cannot reach

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He found that aged liver cells, when inoculated with blood from young people, were able to begin regenerating

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