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Previously, it has been shown that iPSCs bearing this mutation express significantly lower GPX4 [35]

doi: 10.1126/scitranslmed.aad6095

Together, these signaling systems provide a framework for investigating how angiogenic signaling, cytoskeletal organization, and fibroblast-mediated extracellular matrix processes interact in laboratory models of tendon, ligament, and musculoskeletal tissue biology