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Additionally, co-expressing Cas9 protein with multiple guide RNAs can simultaneously edit multiple targets within the mammalian genome

The methyl group in methionine originates from 5-methyl tetrahydrofolate (5-methyl THF), a central metabolite in one-carbon metabolism (the folate cycle) (Figure 1A)

If unexpected FOXO4-DRI side effects are observed, researchers should immediately document all details, including severity, duration, and any accompanying factors