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Phosphorylation of AKT at Ser473 was induced two- to fourfold by knockdown of MEK1 or MEK2 comparing to that in control cells (Fig

Conclusion: GFIPO increased the TG content and enhanced the development of inflammatory and pro-fibrogenic signaling at the gene and protein levels in human PCLS mimicking human NAFL development

doi: 10.3389/fimmu.2025.1683876 Received 11 August 2025 Revised 30 October 2025 Accepted 18 November 2025 Published 05 December 2025 Volume 16 - 2025 Edited by Matheus Mattos, KU Leuven, Belgium Reviewed by Hongquan Wang, Peking University Aerospace School of Clinical Medicine, China Hongjian Pu, University of Pittsburgh, United States Yongjuan Xin, Zhengzhou University, China Updates Copyright 2025 Yi, Jia, Xie, Peng, Zhu, Yin, Luo, Deng and Wan

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Concentrations of ACT were optimized to impair to the same extent as in HEK293 treated with 15 M ACT (loss of 40% growth)