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Pharmacogenetics 7(5):375379 Appendix Appendix Mathematically describing the concentrations at the effect site The changes in the amount of drug at effect site Ae are described [10] by where A1 denotes the amount of drug in compartment 1 (central compartment), from which drug is transferred into the effect compartment by a first-order process with a rate constant k 1e , and it is eliminated from the effect compartment by a first-order process with another rate constant named k e0

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Investigation into the functional impact of the vancomycin C-ring aryl chloride