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Miller School of Medicine, Miami, FL, (5)Charles River Laboratories, Wilmington, MA, (6)Bristol Myers Squibb, (7)Rutgers Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, New Brunswick, NJ, (8)Rutgers Center for Lipid Research, Rutgers, the State University of New Jersey, New Brunswick, NJ Background: Obesity prevalence is rising and comorbidities like non-alcoholic liver disease (NAFLD), which impairs liver function and bile acid signaling, are of growing concern

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Toxicol Appl Pharmacol, 57: 414-424

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The evidence that hypotaurine, through its binding to soluble A, reduces the production and aggregation of oligomers, as well as its ability to lessen the toxicity of -amyloid (A) in primary cultured neurons and amyloid plaques in a mouse model, provides support for this assertion (129)