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Clin Nutr (Edinburgh Scotland)

Of the hundreds of amino acids your body makes, there are 20 that you need to function optimally

Elevated BHB levels suppressed AKT activation in cardiomyocytes, while BDH1 overexpression effectively restored AKT/GSK3 pathway activity and ameliorated BHB-induced mitochondrial dysfunction and cardiomyocytes apoptosis

Chou DE, Gross GJ, Casadei CH, Yugrakh MS

To further validate this relationship, we constructed GCLC knockdown vectors (sh group) and overexpression vectors (OE group) and transfected them into rat neural astrocytes for experimental analysis