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In this Phase II study the aim was to enroll 175 patients with SSc-ILD on stable MMF dose that would be randomized to either receive intravenous abituzumab every 4 weeks for 104 weeks or placebo and the primary end point was the annual rate of change in FVC

In some cases, improvements in sleep and a reduction in behavioral challenges may occur

Sleep deprivation, the next night, you'll get a compensatory effect

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Satoh M, Handa K, Saito S, Tokuyama S, Ito A, Miyao N, Orikasa S, Hakomori S

The Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic checkpoint complex during mitosis