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In contrast, the inhibition of SIRT1 significantly diminished the protective effects of melatonin, suggesting that melatonin plays a crucial role in maintaining mitochondrial function to suppress oxidative stress by modulating the level of SIRT1 in OA progression (137)

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[DOI] [PubMed] [Google Scholar] 135.Chauhan A, Gu F, Essa MM, et al

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