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Androl., 2009, doi: 10.1038/aja.2009.23

At the basic level, it is a loose ligament syndrome

2.4 Aging In the aging process and age-related vascular lesions, cerebral capillaries exhibit morphological changes such as vascular tortuosity increased, circular twisting, irregular capillary diameters, and basement membranes thickened (Ek Olofsson and Englund, 2019)

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As regards the pathogenic mechanisms, the occurrence of an oxidant stress (resulting from an impaired homocysteine metabolism, which modifies the redox status of extra- and intracellular thiols and thus alters the intracellular redox potential) might play a central role in moderate hyperhomocysteinemia-mediated vascular disorders

These findings collectively reveal that maternal metabolic disturbances in DM can remotely impact fetal lung development across the placental barrier, closely associated with gut microbiota metabolism