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In addition, decreasing nuclear Srebf1 levels by deletion of Scap , which is necessary to generate nuclear isoforms of Srebf1 , protected against hepatic steatosis in ob/ob mice and mice under HFDs (55)

12 Alanine scanning mutagenesis has confirmed the importance of Phe23 and 25, Tyr31, Arg36, Arg 37, Val44, and Tyr60, the residues that compose the binding site

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