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While BPC-157, TB-500, KPV, and GHK-Cu injections have not been studied for safety and efficacy in large-scale human clinical trials, some risks may be hypothesized from their mechanisms of action

Similarly, the small molecule MK8722 alleviates OA cartilage degeneration by activating Sestrin 2, which subsequently upregulates BNIP3 and NRF2 to promote mitophagy, thereby reducing oxidative stress and inhibiting chondrocyte ferroptosis (100)