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doi: 10.1038/sj.cdd.4402038 85 MartinonF.BurnsK.TschoppJ

In this context, it has been shown that estrogen supplementation positively regulate the transcription of APE1 and NTH1 in the dorsal raphe of OVX old macaques ( Growth Factors Neuroprotective roles of estrogens are closely related to the synthesis of growth factors

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However, subcutaneous injections are considered a much safer and more convenient form of peptide application in experimental settings

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And I think the animal data are very impressive