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The ratio of reduced glutathione (GSH) to its oxidized form (GSSG) serves as a fundamental marker of the intracellular redox environment

Bhagat Y, Obenaus A, Hamilton M, Mikler J, Kendall E

Ferguson M, Mockett RJ, Shen Y, Orr WC, Sohal RS

S-acetyl glutathione is a chemically protected derivative intended to release reduced glutathione after deacetylation

However, we submit that given APR-246s known activity as a cystine-binding molecule it is likely being sequestered by the cystine made available by NAC, rendering these results, which have also been shown by others, as largely misleading [36, 37]