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J Reprod Dev 61(4):251259 Sun Y, Ito S, Nishio N, Tanaka Y, Chen N, Liu L, Isobe K-I (2015) Enhancement of the acroleininduced production of reactive oxygen species and lung injury by GADD34

These effects were contributed to increase in energy metabolism, insulin signaling pathway and suppression of GSK3/ and ERK 1/2 activity

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Under HO-induced oxidative stress, the expression levels of -catenin and its downstream effector CDH3 are markedly reduced in melanocytes, thereby weakening their antioxidant responses [135].Vitamin D treatment reverses this suppression by promoting Ser9 phosphorylation of GSK3, thereby preventing -catenin degradation and activating downstream transcriptional programs

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Resveratrol protected acrolein-induced ferroptosis and insulin secretion dysfunction via ER-stress- related PERK pathway in MIN6 cells