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For some autoimmune diseases, it may be that the suppression of BH4 is a natural way that the body compensates for the overactivation of the immune response.[ref] In other immune dysregulation situations, it may be that increasing BH4 is helpful

J Clin Psychopharmacol 37(2):239245 Shivavedi N, Chatterjee S, Kumar V (2014) Stress response modulating effects of lactic acid in mice

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In Study 2, hydroxocobalamin infusion was associated with moderate hemodynamic effects, including an increase in systemic vascular resistance, an increase in blood pressure, and a decrease in cardiac output