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Another study demonstrated that only a few mutations were sufficient to induce AS activity in an aminodeoxychorismate synthase, which in its native form does not eliminate pyruvate (Culbertson et al., Anthranilate synthase contains two components, AS-I (TrpE), and AS-II (TrpG), (both EC 4.1.3.27)

Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen

& Hester, P.Y., 2002

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Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects