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Histone acetylation can affect DNA repair in multiple ways, including directly by promoting chromatin relaxation and recruitment of specific DNA-repair factors, or indirectly by promoting the transcription of DNA-repair genes

In addition, the phytochelatins (PCs) are a polymerized version of GSH involved in HMs detoxification by functioning as chelating ligands [6]

Some DUBs may have the ability to cleave isopeptide bonds between these proteins and substrate proteins

Arch Surg 128:2935 Komatsu H, Hoshino A, Funayama M, Kawahara K, Obala F (2003) Oxidative modulation of the glutathione-redox couple enhances lipopolysaccharide-induced interleukin 12 P40 production by a mouse macrophage cell line, J774A.1

Zhao et al., 2016)

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