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Increased cell ageing and exposure to endogenous infectious agents and harmful signals throughout life imbalance the innate and adaptive immune responses, shifting toward greater involvement of innate immune cells, to the detriment of adaptive immunity based on antigen response (Frasca and Blomberg, 2015)

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Elevated intracellular ROS levels in spinal cord dorsal neurons induce the activation of the neuronal ferroptosis pathway and participate in the process of NP

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