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3.4 PPI network The PPI network consisting of 451 intersection targets included 448 nodes and 9753 edges, with an average node degree of 43.5 and an average local clustering coefficient of 0.483 (Figure 4)

4, although the etiology of MDD is still unclear, it is widely accepted that the common pathogenic factors of MDD are genetic, stress, and comorbidity

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Mol Genet Metab 71 : 315320 Werner H, Shen-Orr Z, Rauscher III FJ, Morris JF, Roberts Jr CT, LeRoith D (1995) Inhibition of cellular proliferation by the Wilms' tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression