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Notably, a meta-analysis of the effects of CLA on inflammatory factors in adults indicates that CLA reduces levels of pro-inflammatory cytokines (e.g., TNF- and IL-6), while slightly increasing C-reactive protein (CRP) levels (99)

The mechanism linking RDW to cardiovascular risk likely involves chronic inflammation (RDW reflects inflammatory burden, which drives atherosclerosis), oxidative stress (damages both red blood cells and arterial walls), poor nutritional status (deficiencies affecting red blood cells also affect cardiovascular health), and overall physiological stress and biological aging (high RDW indicates reduced reserve capacity)

GSH was then measured according to kit specifications (Cayman Chemical, Ann Arbor, MI, USA, 703002)

(2) generation of kynurenine and downstream metabolites that activate the aryl hydrocarbon receptor (AhR) to induce regulatory pathways

Sci Trans Med

Screening and analysis of differentially expressed genes of human melanocytes in skin cells mixed culture