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More importantly, activation of TGF- in the right place at the right time is necessary to recruit stem/progenitor cells to participate in the tissue regeneration/remodeling process, whereas sustained abnormalities in TGF- ligand expression, bioavailability, activation, receptor assemblage/stabilization, or post-transcriptional modifications will inevitably disrupt the normal physiology, and lead to pathobiology of major diseases either through the recruitment of excessive progenitors (as seen in osteoarthritis or CamuratiEngelmann disease), or trans-differentiation of resident cells to unfavorable lineage commitment (as seen in epithelial to mesenchymal transition during cancer metastasis or tissue/organ fibrosis)

it has been demonstrated that pH strongly influences the electrostatic and interactions occurring between NSs and dye molecules

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2-Chlorodeoxyadenosine (2-CdA) and cyclophosphamide (Cy) alone or in combination with rituximab (Rit) for previously untreated Waldenstroms macroglobulinemia (WM)

Each of these elements (fire for summer, earth for late summer, metal for autumn, water for winter, and wood for spring) controls certain organs in the body

The MCV was calculated using an HumaCount 5D hematology analyzer (Human GmbH, Wiesbaden, Germany), which provided estimated information on red blood cell volume and shape and size (20)