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Whole-genome selective sweep tests To identify potential selective signatures associated with hypoxia adaptation between populations in high- and low-altitude regions, we selected domestic sheep from plateau ( n = 17) and plain ( n = 20) areas (Supplementary Data 18)

Biological function analysis of high-confidence risk genes To delve into the biological function of HRGs, we conducted pathway enrichment analysis using the top 20 HRGs and the WikiPathways database 60 , a comprehensive resource for pathway-based data analysis

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