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In individuals with iron deficiency anemia, there is a lack of iron available for red blood cell production

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A study in C57BL/6J mice using a dose comparable to a 5000 g tablet (30.46 g/day) for humans found a depletion in Bacteroides but no change in cecal short-chain fatty acids (SCFAs) or markers of dextran sulfate sodium (DSS)-induced colitis with B12 treatment, including colon length and fluorescein isothiocyanate-dextran permeability test [15]

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Nausea or vomiting can reduce food, fluids and supplements even further