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This disruption affects the inhibitory regulation between neurons, thereby disrupting the excitation/inhibition balance in the brain and promoting the emergence of core symptoms of ASD ( Futhermore, the aristaless-related homeobox (Arx) transcription factor, located on the X chromosome, has been implicated in a wide range of neurological disorders, including intellectual disability and epilepsy, as well as ASD

These include specificity of ligand, tissue, cellular localisation and dose, as well as the nature of TAAR1 dimerisation

Given these limitations, interest has grown in plantderived bioactive compounds for their potential neuroprotective and diseasemodifying effects

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Cysteine is the most important amino acid, but B-vitamins (B6, B12, folate) are essential cofactors

doi: 10.1038/ncomms11457 75 YiangGTChouPLHungYTChenJNChangWJYuYLet al