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doi: 10.1016/j.cgh.2012.10.001 170 UhlnMFagerbergLHallstrmBMLindskogCOksvoldPMardinogluAet al

They activate antioxidant enzymes, reduce -tocopherol radicals (tocopheroxyls), inhibit oxidases, mitigate nitrosative stress, and increase the levels of uric acid and low-molecular-weight molecules

The epigenetic modification of autophagy-related genes and other modifications (phosphorylation, ubiquitination, and acetylation) in their coding proteins are regulated by multiple signaling pathways in GBM