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2 Department of Orthopaedic Surgery, Saga Central Hospital, Saga, Japan

This review summarizes and discusses different aspects of IGF-1-mediated protein synthetic and degradation pathways in skeletal muscle and its potential application to therapies to treat patients with reduced skeletal muscle function

control groups)

It is most common in Europe, but is also found at lower, moderate frequencies in Central Asia, the Middle East, North Africa, and among the San and Mbuti Pygmies