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Post Exertional Neuroimmune Exhaustion. CFS uses PEM or 'Post Exertion Malaise' a vague feeling of discomfort or fatigue is an inaccurate and inadequate word for the pathological low threshold fatigability and postexertional Alpha Lipoic Acid: Biological Mechanisms and Health Benefits PMC Subcutaneous Adipose Tissue Diseases: Dercum Disease, Lipedema, Familial Multiple Lipomatosis, and Madelung Disease Endotext NCBI Bookshelf Exploring the Role of Neurotransmitters in Multiple Sclerosis: An Expanded Review ACS Chemical Neuroscience In ME, there is no single approved medication for neuroimmune dysfunction, but clinicians use targeted, off label treatments to calm immune activation, reduce neuroinflammation, and improve signaling between the immune and nervous systems. Diverse Effects of Gut Derived Serotonin in Intestinal Inflammation ACS Chemical Neuroscience

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