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Thereafter, cGMP activates protein kinase G (PKG), whose phosphorylation mediates activities of various membrane channels/pumps, leading to decreased calcium influx through L-type calcium channels and increased calcium sequestration, resulting in smooth muscle relaxation and vascular tone modulation [12]

These effects protect endothelial cells under hypoxic conditions and enhance their anticoagulant and fibrinolytic functions (Wang and Wu, 2010)

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Tashkin DP, Bateman ED, Jones P, et al

The insights will provide a cue for further research and promote the development of novel and effective drugs for treating DILI