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111 Scherz-ShouvalR.ShvetsE.FassE.ShorerH.GilL.ElazarZ

Feng SS, et al

Cellular Biochemistry 441 (1-2), 919

The scientific rationale for peptide-based fat loss research centers on several key mechanisms: Lipolysis Activation: Peptides that increase cAMP in adipocytes (fat cells) activate hormone-sensitive lipase (HSL), which catalyzes the breakdown of stored triglycerides into free fatty acids a process called lipolysis

However, resistance to these drugs has been observed in many cases, necessitating to combine it with other drugs, such as tyrosine kinase inhibitors (TKIs) (imatinib, nilotinib) [5], taxanes (paclitaxel) [6], ribonucleotide reductase inhibitors (Gemcitabine) [7], phosphatidylinositol 3-kinase (PI3K) inhibitors (Alpelisib) [8], among others

Created using CAUSES OF ENDOTHELIAL DYSFUNCTION Lifestyle and environmental risk factors Lifestyle and environmental factors play a significant role in the development of endothelial dysfunction, a key contributor to atherogenesis