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Dziegielewska-Gesiak S, Fatyga E, Kasiarz G, Wilczynski T, Muc-Wierzgon M, Kokot T

System x-C consists of a specific light chain, xCT, and a heavy chain, 4F2, linked by a disulfide bridge (Albrecht et al., 2010), and its activity is inhibited in the context of numerous neuropsychiatric insults including in vitro oxygen deprivation and in vivo chronic cocaine exposure (Baker et al., 2003

10.1210/er.2014-1101 11

Based on this finding we further identified a stem-loop-stem structure with the IRE1 cleavage site close to the 5 end of the gcs-1 transcript that matches the UG^C consensus sequence (Fig