Tau-1 contains a nuclear receptor box, FQNLF (amino acids 2327), and Tau-5 contains the WHTLF motif (amino acids 433437), both of which mediate direct ligand-dependent, interdomain interactions between the NTD and the LBD (termed an N/C interaction), which are important in regulating some, but not all, androgen-dependent genes 40,41,42
Based upon the expression pattern of the candidate genes from this paper, we hypothesize the answer may be placed in vagal afferents and/or associated cell types, as will be discussed in a follow-up paper
Ethics declarations Ethics approval The procedures and protocols used in this study were designed in accordance with the guidelines for animal welfare and the use of animals prepared by the Institutional Animal Care and Ethical Committee of Taif University, Saudi Arabia, for project TURSP-202009
have provided evidence that neuroglial cells can significantly augment neuronal energy metabolism through the coordinated utilization of FAs and KBs, especially under conditions of glycolytic impairment (McMullen et al
Apart from Nlrp3 inflammasome, mitogen-activated protein kinases (MAPK) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) are involved in the pathogenesis of chronic inflammation ( Figure 2 MAPKs are a group of conserved serine/threonine protein kinases, including ERK, JNK, and p38
Discussion HFpEF is regarded a multiorgane syndrome with the heart being affected secondary to numerous comorbidities and pathomechanisms [36, 37]
