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Three-dimensional structure of a pyridoxal-phosphate-dependent enzyme, mitochondrial aspartate aminotransferase

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VacA has some special regions mediating gene expression, including S1 (S1a, S1b, and S1c), S2, I1, I2, M1, and M2 isoforms (Wang et al., 2014), and is capable of directly affecting the activity of vacuoles between HP strains