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have also reported that CAR-mediated metabolic regulation depends on GADD45, as GADD45 knockout blunted the weight reduction and insulin sensitivity induced by the CAR agonist TCPOBOP in HFD-fed mice, mechanistically linked to lipogenesis inhibition in hepatocytes 17

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also soluble in polar aprotic solvents such as DMSO Storage: Store desiccated and protected from light

however, the support for that is weak

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