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Overall, these studies demonstrate that lipolysis signals a homeostatic response by providing ligands to nuclear receptors to regulate gene expression and thereby modulate cellular metabolism (Figure 3)

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Some improvement in symptoms may be seen within a few days to a week after starting treatment, but it can take longer for more severe symptoms to resolve

In further embodiments, the invention encompasses a method of modulating stem cell differentiation by contacting a stem cell expressing NNMT with one or more cations of the invention and with one or more cations chosen from Tables 3a and 3b

The Lancet 368, 16811688 (2006)