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In this context, betaine donates a methyl group to homocysteine to convert it into methionine, thus contributing to the normal metabolism of homocysteine

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While multi-label classification is a straightforward formulation of clinical coding, another approach is through named entity extraction and linking or NER + L (for example in the work of MedCAT 35 and the study of rare disease identification 66,67 with SemEHR 65 ), although less adopted in the recent literature

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