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Loss of neuronal GSH has also been linked to microglial activation and complement-mediated neurodegeneration, further emphasizing the link between redox imbalance and immune dysregulation (Hashimoto et al., 2023)

Specifically, our results show that the lifespan extension induced by mrps-5 RNAi was completely abolished in the C32E8.9 knockout strain, confirming that C32E8.9 is indeed necessary for this beneficial effect

44 The release of zinc from the ER is likely mediated by ZIP7, as ZIP7 predominantly resides in the ER, and silencing ZIP using siRNA prevented the occurrence of the zinc wave

It also increases the production of cortisol, which serves as a precursor to endogenous progesterone and testosterone synthesis

Western blot analysis Whole cell lysates and lung homogenates were prepared with RIPA lysis buffer containing with a protease inhibitor cocktail (GenDEPOT