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Contraception pills or hormone replacement therapy are two such conditions that can give rise to melasma

Barreiro O, Yez-M M, Serrador JM, Montoya MC, Vicente-Manzanares M, Tejedor R et al

During the formation of mixed disulfides, the binding of GSH to protein thiols results in the addition of a glutathione molecule to the protein, leading to the formation of glutathionylated proteins