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Observing this interface of CBS-1 and CBS-2 in isolation, the conformational change is mainly localised in the CBS-1 motif and appears as an unfurling of the butterfly wings of this dimeric arrangement (Supplementary Movie 1)

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The very core of this anabolic program relies on the production of metabolites and co-factors that enable reductive biosynthesis (Walvekar et al., 2018)

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This combination becomes particularly powerful as energy production naturally generates free radicalsNAC helps neutralize these byproducts while NAD maintains optimal energy flow

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