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Another study introduced a recombinant VAR2CSA peptide (rVAR2)-modified activated platelet-mimicking nanoparticles (rVAR2-PM/PLGA-ss-HA) by encasing disulfide-containing PLGA nanoparticles (PLGA-ss-HA) with an activated platelet membrane and packed them with DTX

Discussion Disruption of calcium homeostasis is a key cytotoxic event of a-synucleinopathy Mounting evidence demonstrates that PD-related mutations or environmental risk factors, such as aging and exposure to neurotoxins, are associated with defective calcium homeostasis through a wide variety of mechanisms [3]